Buy Janumet (Metformin, Sitagliptin) online

Buy Janumet (Metformin HCl with Sitagliptin Phosphate) anti-diabetic medication
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HOW AND WHERE TO BUY JANUMET OR VELMETIA (METFORMIN, SITAGLIPTIN) 50 / 500 MG AND 50 / 1000 MG TABLETS OR CAPSULES ONLINE:

JANUMET (METFORMIN, SITAGLIPTIN): PRESCRIBING INFORMATION

DESCRIPTION

Janumet (Sitagliptin Phosphate, Metformin HCl) tablets contain two oral antihyperglycemic drugs used in the management of type 2 diabetes: sitagliptin and metformin hydrochloride.

Sitagliptin

Sitagliptin is an orally-active inhibitor of the dipeptidyl peptidase-4 (DPP-4) enzyme. Sitagliptin is present in Janumet tablets in the form of sitagliptin phosphate monohydrate. Sitagliptin phosphate monohydrate is described chemically as 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate (1:1) monohydrate with an empirical formula of C16H15F6N5OxH3PO4xH2O and a molecular weight of 523.32.

Sitagliptin Phosphate Monohydrate is a white to off-white, crystalline, non-hygroscopic powder. It is soluble in water and N,N-dimethyl formamide; slightly soluble in methanol; very slightly soluble in ethanol, acetone, and acetonitrile; and insoluble in isopropanol and isopropyl acetate.

Metformin Hydrochloride

Metformin Hydrochloride (N,N-dimethylimidodicarbonimidic diamide hydrochloride) is not chemically or pharmacologically related to any other classes of oral antihyperglycemic agents. Metformin Hydrochloride is a white to off-white crystalline compound with a molecular formula of C4H11N5xHCl and a molecular weight of 165.63. Metformin Hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68.

Janumet is available for oral administration as tablets containing 64.25 mg sitagliptin phosphate monohydrate and metformin hydrochloride equivalent to: 50 mg sitagliptin as free base and 500 mg metformin hydrochloride (Janumet 50 mg / 500 mg) or 1000 mg metformin hydrochloride (Janumet 50 mg / 1000 mg). Each film-coated tablet of Janumet contains the following inactive ingredients: polyvinylpyrrolidone, microcrystalline cellulose, sodium lauryl sulfate, and sodium stearyl fumarate. In addition, the film coating contains the following inactive ingredients: polyethylene glycol, polyvinyl alcohol, talc, red iron oxide, titanium dioxide, and black iron oxide.


INDICATIONS AND USAGE

Janumet (Sitagliptin Phosphate, Metformin Hydrochloride) is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both sitagliptin and metformin is appropriate.

Important Limitations of Use

Janumet (Sitagliptin Phosphate, Metformin HCl) should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis, as it would not be effective in these settings.

This medication has not been studied in patients with a history of pancreatitis. It is unknown whether patients with a history of pancreatitis are at increased risk for the development of pancreatitis while using Janumet.


DOSAGE AND ADMINISTRATION

Janumet dosage and administration


DOSAGE FORMS AND STRENGTHS

  • 50 mg / 500 mg tablets are light pink, capsule-shaped, film-coated tablets with "575" debossed on one side.
  • 50 mg / 1000 mg tablets are red, capsule-shaped, film-coated tablets with "577" debossed on one side.


    CONTRAINDICATIONS

    Janumet (Sitagliptin, Metformin) is contraindicated in patients with:

  • Renal disease or renal dysfunction, e.g., as suggested by serum creatinine levels >= 1.5 mg / dl (males), >= 1.4 mg / dl (females) or abnormal creatinine clearance which may also result from conditions such as cardiovascular collapse (shock), acute myocardial infarction, and septicemia.
  • Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma.
  • History of a serious hypersensitivity reaction to Janumet or sitagliptin (one of the components of this medication), such as anaphylaxis or angioedema.
  • Janumet (Sitagliptin Phosphate, Metformin Hydrochloride) should be temporarily discontinued in patients undergoing radiologic studies involving intravascular administration of iodinated contrast materials, because use of such products may result in acute alteration of renal function.


    WARNINGS AND PRECAUTIONS

    Janumet warnings and precautions


    ADVERSE REACTIONS

    Janumet adverse reactions


    DRUG INTERACTIONS

    Janumet drug interactions


    USE IN SPECIFIC POPULATIONS

    Janumet use in specific populations


    OVERDOSAGE

    Janumet overdosage


    CLINICAL PHARMACOLOGY

    Janumet clinical pharmacology


    NONCLINICAL TOXICOLOGY

    Janumet nonclinical toxicology


    CLINICAL STUDIES

    Janumet clinical studies


    HOW SUPPLIED / STORAGE AND HANDLING

    Tablets Janumet, 50 mg / 500 mg, are light pink, capsule-shaped, film-coated tablets with "575" debossed on one side. They are supplied as follows: unit-of-use bottles of 60, 180; unit dose blister packages of 50; bulk bottles of 1000.

    Tablets Janumet, 50 mg / 1000 mg, are red, capsule-shaped, film-coated tablets with "577" debossed on one side. They are supplied as follows: unit-of-use bottles of 60, 180; unit dose blister packages of 50; bulk bottles of 1000.

    Store at 20-25C (68-77F), excursions permitted to 15-30C (59-86F).

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