Metformin / Sitagliptin Online


Buy Janumet (Metformin HCl with Sitagliptin Phosphate) anti-diabetic medication
Cheap qualitative Metformin & Sitagliptin 50/500 mg, 50/1000 mg tablets online



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JANUMET (METFORMIN HYDROCHLORIDE, SITAGLIPTIN PHOSPHATE) TABLETS: DESCRIPTION

Janumet (Sitagliptin Phosphate, Metformin HCl) tablets contain two oral antihyperglycemic drugs used in the management of type 2 diabetes: sitagliptin and metformin hydrochloride.

Sitagliptin

Sitagliptin is an orally-active inhibitor of the dipeptidyl peptidase-4 (DPP-4) enzyme. Sitagliptin is present in Janumet tablets in the form of sitagliptin phosphate monohydrate. Sitagliptin phosphate monohydrate is described chemically as 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate (1:1) monohydrate with an empirical formula of C16H15F6N5OxH3PO4xH2O and a molecular weight of 523.32.

Sitagliptin Phosphate Monohydrate is a white to off-white, crystalline, non-hygroscopic powder. It is soluble in water and N,N-dimethyl formamide; slightly soluble in methanol; very slightly soluble in ethanol, acetone, and acetonitrile; and insoluble in isopropanol and isopropyl acetate.

Metformin Hydrochloride

Metformin Hydrochloride (N,N-dimethylimidodicarbonimidic diamide hydrochloride) is not chemically or pharmacologically related to any other classes of oral antihyperglycemic agents. Metformin Hydrochloride is a white to off-white crystalline compound with a molecular formula of C4H11N5xHCl and a molecular weight of 165.63. Metformin Hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68.

Janumet is available for oral administration as tablets containing 64.25 mg sitagliptin phosphate monohydrate and metformin hydrochloride equivalent to: 50 mg sitagliptin as free base and 500 mg metformin hydrochloride (Janumet 50 mg / 500 mg) or 1000 mg metformin hydrochloride (Janumet 50 mg / 1000 mg). Each film-coated tablet of Janumet contains the following inactive ingredients: polyvinylpyrrolidone, microcrystalline cellulose, sodium lauryl sulfate, and sodium stearyl fumarate. In addition, the film coating contains the following inactive ingredients: polyethylene glycol, polyvinyl alcohol, talc, red iron oxide, titanium dioxide, and black iron oxide.



Janumet (Metformin HCl, Sitagliptin Phosphate) related pharmaceutical drugs and medications

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Januvia medication guide
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  • Merck
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