Metformin / Sitagliptin Online


Buy Janumet (Metformin HCl with Sitagliptin Phosphate) anti-diabetic medication
Cheap qualitative Metformin & Sitagliptin 50/500 mg, 50/1000 mg tablets online



HOW AND WHERE TO ORDER JANUMET (METFORMIN, SITAGLIPTIN) 50 / 500 MG AND 50 / 1000 MG TABLETS OR CAPSULES ONLINE:

CHEAP MEDS

from $2.08 per pill
5% discount coupon: 5OFF


MEDICINES STORE

from $2.95 per pill
10% discount coupon: MSD10


DISCOUNT MEDS

from $3.49 per pill
10% discount coupon: dmeds10




JANUMET (METFORMIN HYDROCHLORIDE, SITAGLIPTIN PHOSPHATE) TABLETS: MECHANISM OF ACTION

Janumet

Janumet combines two antihyperglycemic agents with complementary mechanisms of action to improve glycemic control in patients with type 2 diabetes: sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and metformin hydrochloride, a member of the biguanide class.

Sitagliptin

Sitagliptin is a DPP-4 inhibitor, which is believed to exert its actions in patients with type 2 diabetes by slowing the inactivation of incretin hormones. Concentrations of the active intact hormones are increased by sitagliptin, thereby increasing and prolonging the action of these hormones. Incretin hormones, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine throughout the day, and levels are increased in response to a meal. These hormones are rapidly inactivated by the enzyme DPP-4. The incretins are part of an endogenous system involved in the physiologic regulation of glucose homeostasis. When blood glucose concentrations are normal or elevated, GLP-1 and GIP increase insulin synthesis and release from pancreatic beta cells by intracellular signaling pathways involving cyclic AMP. GLP-1 also lowers glucagon secretion from pancreatic alpha cells, leading to reduced hepatic glucose production. By increasing and prolonging active incretin levels, sitagliptin increases insulin release and decreases glucagon levels in the circulation in a glucose-dependent manner. Sitagliptin demonstrates selectivity for DPP-4 and does not inhibit DPP-8 or DPP-9 activity in vitro at concentrations approximating those from therapeutic doses.

Metformin Hydrochloride

Metformin is an antihyperglycemic agent which improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Its pharmacologic mechanisms of action are different from other classes of oral antihyperglycemic agents. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Unlike sulfonylureas, metformin does not produce hypoglycemia in either patients with type 2 diabetes or normal subjects (except in special circumstances and does not cause hyperinsulinemia. With metformin therapy, insulin secretion remains unchanged while fasting insulin levels and day-long plasma insulin response may actually decrease.



Janumet (Metformin HCl, Sitagliptin Phosphate) related pharmaceutical drugs and medications

Trade name of the drug Pharmaceutical forms and doses Companies
Onglyza medication guide
  • Tablets, Film-Coated; Oral; Saxagliptin Hydrochloride 2.5 mg
  • Tablets, Film-Coated; Oral; Saxagliptin Hydrochloride 5 mg
  • AstraZeneca
  • DKSH
  • Kyowa Hakko Kirin


  • Recent posts:

  • Order Janumet (Metformin, Sitagliptin) Online
  • Janumet prescribing information



    Disclaimer: Please note, this website is not an online pharmacy, drugstore and related online pharma shop. It does not sell, supply or advertise any prescription and OTC drugs, medications, other goods and services. All reviews, links, lists, databases, texts, and other content on the website are provided free and only for informational and educational purposes. Medical content on this website, including drug names, indications, contraindication, side effects, categories, classifications, forms, doses, prices, other health and pharmaceutical information are taken only from trusted and authoritative professional sources (see "References"), reviewed and prepared by our licensed experts, content inspectors and editors.
    You should always consult your doctor or other healthcare professional before using any medication. This website, our staff and support do not provide own medical instructions and advices.
    All brands and trade names appearing on the website are registered trademarks of their respective companies.
    Remember that buying drugs and medicines online is a responsibility only of customers, sellers and suppliers regarding existing legislation in their jurisdictions.

    Share us in social media:

    Copyright © 2015-2020 Metformin-Sitagliptin.buymedsonline.org, a division of Pharma-Doctor.com pharmaceutical network. All rights reserved.

    Home Page | Privacy Policy | Cookies Policy | Terms of Service | Contact Us