Metformin / Sitagliptin Online


Buy Janumet (Metformin HCl with Sitagliptin Phosphate) anti-diabetic medication
Cheap qualitative Metformin & Sitagliptin 50/500 mg, 50/1000 mg tablets online



HOW AND WHERE TO ORDER JANUMET (METFORMIN, SITAGLIPTIN) 50 / 500 MG AND 50 / 1000 MG TABLETS OR CAPSULES ONLINE:

CHEAP MEDS

from $2.08 per pill
5% discount coupon: 5OFF


MEDICINES STORE

from $2.95 per pill
10% discount coupon: MSD10


DISCOUNT MEDS

from $3.49 per pill
10% discount coupon: dmeds10




JANUMET (METFORMIN HYDROCHLORIDE, SITAGLIPTIN PHOSPHATE) TABLETS: USE IN PREGNANCY

Pregnancy Category B

Janumet

There are no adequate and well-controlled studies in pregnant women with Sitagliptin with Metformin (Janumet) or its individual components; therefore, the safety of this drug in pregnant women is not known. Janumet should be used during pregnancy only if clearly needed.

Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., maintains a registry to monitor the pregnancy outcomes of women exposed to Janumet (Sitagliptin Phosphate, Metformin Hydrochloride) while pregnant. Health care providers are encouraged to report any prenatal exposure to this medicine by calling the Pregnancy Registry.

No animal studies have been conducted with the combined products in Sitagliptin Phosphate with Metformin HCl (Janumet) to evaluate effects on reproduction. The following data are based on findings in studies performed with sitagliptin or metformin individually.

Sitagliptin

Reproduction studies have been performed in rats and rabbits. Doses of sitagliptin up to 125 mg / kg (approximately 12 times the human exposure at the maximum recommended human dose) did not impair fertility or harm the fetus. There are, however, no adequate and well-controlled studies with sitagliptin in pregnant women.

Sitagliptin administered to pregnant female rats and rabbits from gestation day 6 to 20 (organogenesis) was not teratogenic at oral doses up to 250 mg / kg (rats) and 125 mg / kg (rabbits), or approximately 30 and 20 times human exposure at the maximum recommended human dose (MRHD) of 100 mg per day based on AUC comparisons. Higher doses increased the incidence of rib malformations in offspring at 1000 mg / kg, or approximately 100 times human exposure at the MRHD.

Sitagliptin administered to female rats from gestation day 6 to lactation day 21 decreased body weight in male and female offspring at 1000 mg / kg. No functional or behavioral toxicity was observed in offspring of rats.

Placental transfer of sitagliptin administered to pregnant rats was approximately 45% at 2 hours and 80% at 24 hours postdose. Placental transfer of sitagliptin administered to pregnant rabbits was approximately 66% at 2 hours and 30% at 24 hours.

Metformin Hydrochloride

Metformin was not teratogenic in rats and rabbits at doses up to 600 mg / kg per day. This represents an exposure of about 2 and 6 times the maximum recommended human daily dose of 2 g based on body surface area comparisons for rats and rabbits, respectively. Determination of fetal concentrations demonstrated a partial placental barrier to metformin.



Janumet (Metformin HCl, Sitagliptin Phosphate) related pharmaceutical drugs and medications

Trade name of the drug Pharmaceutical forms and doses Companies
Onglyza use in pregnancy
  • Tablets, Film-Coated; Oral; Saxagliptin Hydrochloride 2.5 mg
  • Tablets, Film-Coated; Oral; Saxagliptin Hydrochloride 5 mg
  • AstraZeneca
  • DKSH
  • Four Star
  • Zuellig Pharma


  • Recent posts:

  • Order Janumet (Metformin, Sitagliptin) Online
  • Janumet prescribing information



    Disclaimer: Please note, this website is not an online pharmacy, drugstore and related online pharma shop. It does not sell, supply or advertise any prescription and OTC drugs, medications, other goods and services. All reviews, links, lists, databases, texts, and other content on the website are provided free and only for informational and educational purposes. Medical content on this website, including drug names, indications, contraindication, side effects, categories, classifications, forms, doses, prices, other health and pharmaceutical information are taken only from trusted and authoritative professional sources (see "References"), reviewed and prepared by our licensed experts, content inspectors and editors.
    You should always consult your doctor or other healthcare professional before using any medication. This website, our staff and support do not provide own medical instructions and advices.
    All brands and trade names appearing on the website are registered trademarks of their respective companies.
    Remember that buying drugs and medicines online is a responsibility only of customers, sellers and suppliers regarding existing legislation in their jurisdictions.

    Share us in social media:

    Copyright © 2015-2020 Metformin-Sitagliptin.buymedsonline.org, a division of Pharma-Doctor.com pharmaceutical network. All rights reserved.

    Home Page | Privacy Policy | Cookies Policy | Terms of Service | Contact Us