Metformin / Sitagliptin Online


Buy Janumet (Metformin HCl with Sitagliptin Phosphate) anti-diabetic medication
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JANUMET (METFORMIN HYDROCHLORIDE, SITAGLIPTIN PHOSPHATE) TABLETS: USE IN SPECIFIC POPULATIONS

Nursing Mothers

No studies in lactating animals have been conducted with the combined components of Janumet (Sitagliptin Phosphate, Metformin HCl). In studies performed with the individual components, both sitagliptin and metformin are secreted in the milk of lactating rats. It is not known whether sitagliptin is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Janumet (Sitagliptin, Metformin) is administered to a nursing woman.

Pediatric Use

Safety and effectiveness of Sitagliptin with Metformin (Janumet) in pediatric patients under 18 years have not been established.

Geriatric Use

Janumet

Because sitagliptin and metformin are substantially excreted by the kidney, and because aging can be associated with reduced renal function, Janumet (Sitagliptin Phosphate, Metformin Hydrochloride) should be used with caution as age increases. Care should be taken in dose selection and should be based on careful and regular monitoring of renal function.

Sitagliptin

Of the total number of subjects (N=3884) in Phase II and III clinical studies of sitagliptin, 725 patients were 65 years and over, while 61 patients were 75 years and over. No overall differences in safety or effectiveness were observed between subjects 65 years and over and younger subjects. While this and other reported clinical experience have not identified differences in responses between the elderly and younger patients, greater sensitivity of some older individuals cannot be ruled out.

Metformin Hydrochloride

Controlled clinical studies of metformin did not include sufficient numbers of elderly patients to determine whether they respond differently from younger patients, although other reported clinical experience has not identified differences in responses between the elderly and young patients. Metformin should only be used in patients with normal renal function. The initial and maintenance dosing of metformin should be conservative in patients with advanced age, due to the potential for decreased renal function in this population. Any dose adjustment should be based on a careful assessment of renal function.



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